Bupropion is a NDRI. Then you would have to add on an SSRI. However, 2 antidepressants aren’t usually prescribed together.
Edit: dextromethorphan/bupropion (brand name Auvelity). The dextromethorphan hits multiple targets including NMDA and sigma 1, but technically has some inhibition activity to SERT. I am unsure how strong that activity is, whether it is dose dependant, if its an active metabolite etc. Also should point out that nowhere on the manufacturers website do they talk about using the dextromethorphan to hit serotonin. According to the website, the true mechanism of action of Auvelity for treating MDD is not well understood.
Bupropion is a NDRI. Then you would have to add on an SSRI. However, 2 antidepressants aren’t usually prescribed together.
Edit: dextromethorphan/bupropion (brand name Auvelity). The dextromethorphan hits multiple targets including NMDA and sigma 1, but technically has some inhibition activity to SERT. I am unsure how strong that activity is, whether it is dose dependant, if its an active metabolite etc. Also should point out that nowhere on the manufacturers website do they talk about using the dextromethorphan to hit serotonin. According to the website, the true mechanism of action of Auvelity for treating MDD is not well understood.
Edit2: check out this page. Gives more info and some references. Apparently fairly strong against SERT. [(https://tmedweb.tulane.edu/pharmwiki/doku.php/dextromethorphan)]